Integrating multiple-unit pellet system and gastro-retentive drug delivery systems: A new era in oral drug delivery
Institutes of Pharmaceutical Science, Sage University, Indore, MP-452020, India.
Review
World Journal of Biology Pharmacy and Health Sciences, 2024, 20(02), 514–524.
Article DOI: 10.30574/wjbphs.2024.20.2.0898
Publication history:
Received on 03 October 2024; revised on 15 November 2024; accepted on 17 November 2024
Abstract:
Delivery Systems (GRDDS) are advanced pharmaceutical formulations designed to extend the residence time of drugs in the gastrointestinal (GI) tract, thereby enhancing the bioavailability of medications, particularly those with narrow absorption windows or significant first-pass metabolism. By improving drug solubility and absorption, GRDDS offers a strategic approach to optimizing therapeutic outcomes. Meanwhile, Multiple-Unit Pellet Systems (MUPS) utilize a multiparticulate design consisting of small, spherical pellets that enhance the pharmacokinetic and pharmacodynamic profiles of drugs, providing several advantages over traditional single-unit dosage forms. The integration of MUPS with GRDDS presents a novel formulation strategy aimed at harnessing the strengths of both systems. This combination not only aims to improve drug absorption but also to optimize therapeutic efficacy and enhance patient compliance. By leveraging the benefits of extended gastric retention and uniform drug distribution, this synergistic approach holds significant promise for advancing drug delivery technologies and improving clinical outcomes.
Keywords:
GRDDS; MUPS; Bioavailability; Targeted Delivery; Mucoadhesive.
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