Ensuring safety and monitoring adverse events in clinical trials: Challenges and innovations

Shaik Harun Rasheed *

Gurunanak Institutions Technical Campus-School of Pharmacy Hyderabad 501506 Telangana, India.
 
Review
World Journal of Biology Pharmacy and Health Sciences, 2024, 20(01), 454–457.
Article DOI: 10.30574/wjbphs.2024.20.1.0798
Publication history: 
Received on 22 December 2023; revised on 16 October 2024; accepted on 19 October 2024
 
Abstract: 
Safety and adverse events (AEs) monitoring in clinical trials are critical to ensuring participant safety and the successful development of new therapies. Effective monitoring not only protects patients but also helps identify any risks associated with the investigational product. This paper elaborates on the methodologies used to detect, categorize, and report adverse events during clinical trials, and how these processes are governed by stringent regulatory frameworks. Additionally, the discussion highlights the role of pharmacovigilance systems, the ethical obligations researchers face in AE reporting, and the technological innovations that are transforming safety monitoring. Challenges, including under-reporting, data variability, and interpretation difficulties, are examined in depth. Ultimately, advancements in real-time data collection, adaptive trial designs, and artificial intelligence (AI) are promising to improve the accuracy and timeliness of adverse event monitoring, shaping the future of clinical research and patient safety.
 
Keywords: 
Adverse events; Clinical trials; Safety monitoring; Pharmacovigilance; Serious adverse events; Data interpretation; Real-time monitoring
 
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