Comparison of hormonal levels between infertile PCOS and non-PCOS females
1 Department of Infertility and Assisted Reproductive Techniques, Kamal Alsamarai Teaching Hospital, Iraq, Baghdad.
2 Department of Biochemistry, Al-Kindi Teaching Hospital, Iraq, Baghdad.
3 Department of Microbiology, Al-Kindi Teaching Hospital, Iraq, Baghdad.
Research Article
World Journal of Biology Pharmacy and Health Sciences, 2024, 20(02), 398–402.
Article DOI: 10.30574/wjbphs.2024.20.2.0805
Publication history:
Received on 10 September 2024; revised on 11 November 2024; accepted on 13 November 2024
Abstract:
Background: Polycystic ovary syndrome (PCOS) is a complex condition characterized by elevated androgen levels, menstrual irregularities cystic ovaries. Other clinical features include obesity, acne, amenorrhea, excessive hair growth, and infertility. PCOS has been linked to insulin resistance and obesity and many patients with PCOS have insulin resistance and hyper-insulinemia, which play a significant role in the pathogenesis of PCOS
Method: This study was conducted during the period starting from November 2022 to May 2023. One hundred infertile female patients aged range 18–46 years.
Women complaining from infertility included in this study were divided into 2 groups:
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Group I: PCOS group, including 42 females diagnosed with PCOS.
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Group II: Non-PCOS group, involving 58 females with either male factors or unexplained causes of infertility.
Results: BMI was significantly higher among PCOS females (28.61 ± 1.06 vs.25.62 ± 1.65; p=0.046), there was significantly higher LH levels (6.12 ± 0.12 vs. 4.59 ± 0.31; p=004), LH/FSH ratio (1.20 ± 0.12 vs. 0.78 ± 0.05; p=0.001) and significantly lower FSH levels among PCOS patients (5.62 ± 0.62 vs. 6.67 ± 0.58; p=0.043). There were also no significant correlations among PCOS women between BMI with LH, FSH, LH/FSH ratio, E2, prolactin and testosterone hormones
Keywords:
Polycystic ovary syndrome; Infertility; Hyper-insulinemia; Insulin resistance
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